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- Title
A highly therapeutic and selective delivery system for curcumin based on nanocellulose and folic acid.
- Authors
Cui, Meng; Tian, Yan; Liu, Yi; Liu, Hao; Tao, Jinsong
- Abstract
Curcumin (CUR) is an emerging natural agent for cancer therapy. However, the low therapeutic efficacy and weak selectivity of CUR still severely limit its application. Here, by utilizing cellulose nanocrystals (CNCs) as nanocarriers, we simultaneously loaded CUR and folic acid (FA) and developed a hybrid nanoparticle to improve the therapeutic efficacy and selectivity. Within this system, the solubility and stability of CUR were improved remarkably. The solubility was increased from 0.89 to 6.07 μg/mL. The stability was enhanced with 95% of the curcumin content remaining in the PBS buffer. In addition, FA was effectively grafted onto the nanoparticles, allowing the system to demonstrate potential targeted properties. The well-designed system shows an excellent loading capacity of 26.6 μg/mg due to the rod-like morphology of CNCs. And meanwhile, it also presents a pH-dependent and high release rate of 87.45%. By using CNCs as bridge nanocarriers, each of the aforementioned functions is included in a single hybrid nanoparticle. The all-inclusive integration could enhance the therapeutic efficacy and selectivity of CUR, leading to excellent therapeutic outcomes. We anticipate this work may take a close step toward CUR clinical application and provide a novel strategy for cancer therapy.
- Subjects
CURCUMIN; CELLULOSE nanocrystals; NANOPARTICLES; FOLIC acid; NANOCARRIERS; TREATMENT effectiveness
- Publication
Cellulose, 2023, Vol 30, Issue 8, p5113
- ISSN
0969-0239
- Publication type
Article
- DOI
10.1007/s10570-023-05122-x