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- Title
An oligosaccharide fraction from Korean mugwort herb suppresses death of the mouse thymocytes in culture by down-regulating the Fas death receptor gene.
- Authors
Kyung Chung, Hye; Kyong Bae, Eun; Jung Ji, Hee; Suk Hwang, Jung; Woon Park, Dong; Eun Kim, Jung; Jin Jung, Hwa; Ju Choi, Hyun; Seok Lee, Dong; Joo Youn, Hyun
- Abstract
Korean mugwort herb is a preparation of dried leaves from Artemisia species and has been used as a traditional medicine in Asia. An oligosaccharide fraction, AVF3, purified from the preparation promoted survival of the mouse thymocytes in culture. A mouse gene array study suggests that the AVF3 may modulate Fas/FasL dependent apoptotic cell death and thus has influence on the survival of the thymocytes in culture. RT-PCR analysis confirmed the down-regulation of the Fas gene by the AVF3 treatment, supporting that the AVF3 modulated thymocyte death by suppressing the Fas gene expression.
- Subjects
ARTEMISIA vulgaris; OLIGOSACCHARIDES; APOPTOSIS; GENE expression; MICE; GENOMICS
- Publication
Biotechnology Letters, 2003, Vol 25, Issue 18, p1549
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1025482516404