We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enzymatic synthesis of amino acid-sugar alcohol conjugates in organic media.
- Authors
Jeon, Gyu-Jong; Park, Oh-Jin; Hur, Byung-Ki; Yang, Ji-Won
- Abstract
Amino acid-sugar alcohol conjugates were synthesized by a commercial serine protease, Optimase M-440, in organic media. Optimase M-440 showed broad substrate specificity towards N-t-Boc-protected l-amino acids as acyl donors and sugar alcohols as nucleophiles. Among various solvents tested Optimase M-440 showed the highest activity in pyridine. The regioselective acylation of the primary -OH groups of sugar alcohols gave the amino acid conjugates in good yields without byproducts.
- Subjects
ENZYMES; AMINO acids; ALCOHOLS (Chemical class); SUGARS; BIOCONJUGATES; ORGANIC solvents
- Publication
Biotechnology Letters, 2001, Vol 23, Issue 12, p929
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1010598031929