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- Title
Metal-responsive gene regulation and metal transport in Helicobacter species.
- Authors
Belzer, Clara; Stoof, Jeroen; van Vliet, Arnoud H. M.
- Abstract
Helicobacter species are among the most successful colonizers of the mammalian gastrointestinal and hepatobiliary tract. Colonization is usually lifelong, indicating that Helicobacter species have evolved intricate mechanisms of dealing with stresses encountered during colonization of host tissues, like restriction of essential metal ions. The recent availability of genome sequences of the human gastric pathogen Helicobacter pylori, the murine enterohepatic pathogen Helicobacter hepaticus and the unannotated genome sequence of the ferret gastric pathogen Helicobacter mustelae has allowed for comparitive genome analyses. In this review we present such analyses for metal transporters, metal-storage and metal-responsive regulators in these three Helicobacter species, and discuss possible contributions of the differences in metal metabolism in adaptation to the gastric or enterohepatic niches occupied by Helicobacter species.
- Publication
BioMetals, 2007, Vol 20, Issue 3/4, p417
- ISSN
0966-0844
- Publication type
Article
- DOI
10.1007/s10534-006-9028-9