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- Title
Excess Mortality in Kidney and Kidney-Pancreas Transplant Recipients in the COVID-19 Pandemic in Portugal--A Cohort Study.
- Authors
Coimbra, Miguel T.; Francisco, José A. T. S.; Freitas, Joana C.; Carvalho, Renata V.; Vilela, Sara R. B.; Ribeiro, Catarina I. C. D.; Silvano, José L. C. S. L.; Pedroso, Sofia; Almeida, Manuela; Martins, La Salete; Malheiro, Jorge
- Abstract
The COVID-19 pandemic increased morbidity and mortality worldwide, particularly in the Kidney and Kidney-Pancreas Transplant Recipient (KTR/KPTR) population. Aiming at assessing the absolute and relative excess mortality (EM) in a Portuguese KTR/KPTR cohort, we conducted a retrospective observational study of two KTR/KPTRs cohorts: cohort 1 (P1; n = 2,179) between September/2012 and March/2020; cohort 2 (P2; n = 2067) between March/2020, and August/2022. A correlation between relative and absolute EM and age, sex, time from transplantation and cause of death was explored. A total of 145 and 84 deaths by all causes were observed in P1 and P2, respectively. The absolute EM in P2 versus P1 was 19.2 deaths (observed/expected mortality ratio 1.30, p = 0.006), and the relative EM was 1.47/1,000 person-months (95% CI 1.11-1.93, p = 0.006). Compared to the same period in the general population, the standardized mortality rate by age in P2 was 3.86 (95% CI 2.40-5.31), with a peak at 9.00 (95% CI 4.84-13.16) in P2C. The higher EM identified in this population was associated, mainly, with COVID-19 infection, with much higher values during the second seasonal COVID-19 peak when compared to the general population, despite generalized vaccination. These highlight the need for further preventive measures and improved therapies in these patients.
- Subjects
COVID-19 pandemic; KIDNEY transplantation; COHORT analysis; COVID-19; MORTALITY
- Publication
Transplant International, 2023, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2023.11655