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- Title
A prostate cancer vaccine comprising whole cells secreting IL-7, effective against subcutaneous challenge, requires local GM-CSF for intra-prostatic efficacy.
- Authors
Schroten-Loef, Caroline; de Ridder, Corrina M. A.; Reneman, Suzanne; Crezee, Marije; Dalgleish, Angus; Todryk, Stephen M.; Bangma, Chris H.; Kraaij, Robert
- Abstract
A panel of cytokine-secreting RM-9 prostate cancer cells were tested as whole cell vaccines to determine their capacity to evoke an anti-prostate cancer immune response. In our model, vaccines secreting mGM-CSF or mIL-7 resulted in the highest increase in circulating T lymphocytes after vaccination, prolonged survival and, in a proportion of animals, tumor-free survival. Anti-tumor effects were more evident after a subcutaneous RM-9 challenge than after an intraprostatic challenge. However, when the RM-9/mGM-CSF cell line was used as intraprostatic tumor challenge, protection after RM-9/mIL-7 vaccination was restored.
- Subjects
PROSTATE cancer; CANCER prevention; VACCINATION; IMMUNE response; TUMORS
- Publication
Cancer Immunology, Immunotherapy, 2009, Vol 58, Issue 3, p373
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-008-0560-z