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- Title
IGF1 and PPARG polymorphisms are associated with reduced estimated glomerular filtration rate in a cohort of children and adolescents with type 1 diabetes.
- Authors
Zusi, Chiara; Rioda, Marco; Maguolo, Alice; Emiliani, Federica; Unali, Ilaria; Costantini, Silvia; Corradi, Massimiliano; Contreas, Giovanna; Morandi, Anita; Maffeis, Claudio
- Abstract
Introduction: Several genetic loci have been associated with diabetic nephropathy; however, the underlying genetic mechanisms are still poorly understood, with no robust candidate genes identified yet. Aim: We aimed to determine whether two polymorphisms, previously associated with renal decline, influence kidney impairment evaluating their association with markers of renal function in a pediatric population with type 1 diabetes (T1D). Material and methods: Renal function was evaluated by glomerular filtration rate (eGFR) and albumin-to-creatinine ratio (ACR) in a cohort of pediatric subjects with T1D (n = 278). Risk factors for diabetes complications (diabetes duration, blood pressure, HbA1c) were assessed. The IGF1 rs35767 and PPARG rs1801282 SNPs were genotyped by TaqMan RT-PCR system. An additive genetic interaction was calculated. Association analysis between markers of renal function and both SNPs or their additive interaction were performed. Results: Both SNPs showed a significant association with eGFR: the A allele of rs35767 or the C allele of rs1801282 were associated to reduced eGFR compared to G alleles. Multivariate regression analysis adjusted for age, sex, z-BMI, T1D duration, blood pressure and Hba1c values showed that the additive genetic interaction was independently associated with lower eGFR (β = −3.59 [−6.52 to −0.66], p = 0.017). No associations were detected between SNPs, their additive interaction and ACR. Conclusions: These results provide new insight into the genetic predisposition to renal dysfunction, showing that two polymorphisms in IGF1 and PPARG genes can lead to a reduction in renal filtration rate leading these patients to be exposed to a higher risk of early renal complications.
- Subjects
TYPE 1 diabetes; GLOMERULAR filtration rate; DIABETIC nephropathies; KIDNEY physiology; DIABETES complications; CHILD patients
- Publication
Acta Diabetologica, 2023, Vol 60, Issue 10, p1351
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-023-02128-6