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- Title
Acylation of 3,4-Dihydropyrrolo[1,2-a]pyrazines.
- Authors
Terenin, V. I.; Kabanova, E. V.; Tselishcheva, N. A.; Kovalkina, M. A.; Pleshkova, A. P.; Zyk, N. V.
- Abstract
The direction of trifluoroacetylation with trifluoroacetic anhydride of 3,4-dihydropyrrolo[1,2-a]pyrazines containing an alkyl or aralkyl substituent in position 1 depends on both the structure of the 3,4-dihydropyrrolo[1,2-a]pyrazine starting materials and on the ratio of reagent:substrate. It may lead to both mono- and disubstituted products. Trifluoroacetylation of 1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazines occurs at the methyl group. Acetylation of 3,4-dihydropyrrolo[1,2-a]pyrazines leads only to N-acetyl-substituted reaction products.
- Subjects
PYRIDAZINES; ACYLATION; ANHYDRIDES; CHEMICAL reactions; METHYL groups; PYRIDINE
- Publication
Chemistry of Heterocyclic Compounds, 2004, Vol 40, Issue 3, p351
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1023/B:COHC.0000028632.61226.cd