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- Title
Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C.
- Authors
Arici, Mustafa; Brown, Jeremy; Williams, Matthew; Harris, Kevin P. G.; Walls, John; Brunskill, Nigel J.
- Abstract
Background. Proteinuric renal disease is associated with accumulation of tubulointerstitial matrix proteins. Human proximal tubular cells (PTCs) produce fibronectin in response to serum proteins but not albumin alone. It has been suggested that renal toxicity of filtered albumin depends on its lipid moiety. We therefore investigated the functional consequences of different fatty acids (FAs) carried on human albumin after exposure to human PTCs in culture.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, Issue 10, p1751
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.10.1751