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- Title
Development of new antibiotic resistance in methicillin-resistant but not methicillin-susceptible Staphylococcus aureus.
- Authors
Wadsworth, Sandra J.; Kim, Ki-Ho; Satishchandran, Vilas; Axelrod, Peter; Truant, Allan L.; Suh, Byungse; Wadsworth, S J; Kim, K H; Satishchandran, V; Axelrod, P; Truant, A L; Suh, B
- Abstract
The frequency of infections caused by multidrug-resistant Staphylococcus aureus continues to increase while the numbers of alternative therapeutic agents remain limited. To investigate the changing patterns of in-vitro susceptibility of S. aureus to 16 antibiotics, 190 clinical isolates from two different years were studied. The MICs of methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains isolated in 1987 were compared with those of similar numbers of strains isolated in 1989. For MRSA > or = 90% of isolates from both years were resistant to clindamycin, gentamicin and erythromycin. These strains remained highly susceptible to vancomycin (100%), minocycline (90%) and rifampicin (100%). The greatest increase in resistance was observed for ofloxacin (2% in 1987 vs 62% in 1989); cross-resistance to all of the quinolones tested was demonstrated. MSSA strains remained susceptible to vancomycin (100%), minocycline (98%), rifampicin (100%), clindamycin (90%), gentamicin (90%) and ciprofloxacin (98%). It is concluded that methicillin susceptibility is a useful marker for selecting potential agents for the treatment of infections caused by S. aureus. A combination of minocycline and rifampicin may be a useful alternative to vancomycin for treating MRSA infections.
- Subjects
DRUG resistance in microorganisms; IMMUNITY; METHICILLIN resistance; MICROBIAL sensitivity tests; STAPHYLOCOCCUS aureus
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1992, Vol 30, Issue 6, p821
- ISSN
0305-7453
- Publication type
journal article