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- Title
Ciprofloxacin in experimental aortic valve endocarditis due to Pseudomonas aeruginosa.
- Authors
Bayer, Arnold S.; Blomquist, Ingrid K.; Kim, Kwang Sik
- Abstract
Left-sided endocarditis caused by is frequently associated with failure of medical therapy in man. The efficacy of ciprofloxacin and netilmicin + azlocillin has been studied in 79 rabbits with aortic valve endocarditis caused by a serum-resistant strain of . Infected animals received either: no therapy; ciprofloxacin (80 mg/kg/day); or netilmicin (6.5 mg/kg/day) + azlocillin (400 mg/kg/day). Ciprofloxacin significantly lowered vegetation titers of at days 6 and 10 of therapy compared with netilmicin + azlocillin (< 0.001). Similarly, ciprofloxacin was significantly more effective in sterilizing vegetations ( < 0.005), curing endocarditis (< 0.001), and preventing bacteriological relapse after discontinuing antibiotic therapy (< 0.005). Both antibiotic regimens were equally effective in sterilizing renal abscesses. Resistance to azlocillin was occasionally observed among isolates within cardiac vegetations during the second week of therapy, but not to ciprofloxacin or netilmicin.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 17, Issue 5, p641
- ISSN
0305-7453
- Publication type
Article