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- Title
Chemische Aspekte der Penicillin-Allergie: die direkte Bildung der Penicilloyl-Determinanten aus Penicillin.
- Authors
Schneider, C. H.; De Weck, A. L.
- Abstract
The aminolysis of two penicillin-like compounds which cannot form penicillenic acid has been studied: 6-Aminopenicillanic acid (which is highly immunogenic) reacts directly with ε-amino groups at pH 7,4 under CO2-free conditions; the possible role of its polymerisation in this reaction remains to be studied., 6-Dinitrophenylamino-penicillanic acid reacts with εamino groups at pH 7,4 as fast as benzylpenicillin and other penicillins. Its immunogenicity in the rabbit is similar to that of benzylpenicillin.
- Publication
Helvetica Chimica Acta, 1966, Vol 49, Issue 5, p1707
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19660490533