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- Title
Antikonvulsive Komedikation von Topiramat und Zonisamid. Eine erste Analyse der Verträglichkeit bei 19 Patienten.
- Authors
Bös, M.; Bauer, J.
- Abstract
We analysed patients with focal epilepsies treated with zonisamide (ZNS) as add-on treatment to topiramate (TPM) and other antiepileptic drugs (mean 2). Twenty-five patients were evaluated, and follow-up data were available in 19 (12 women, seven men, mean age 34 years). The mean time until first follow-up investigation was 17 weeks. At that point in time the mean ZNS dosage was 344 mg and mean TPM dosage was 398 mg. Eight patients (42%) achieved seizure frequency reduced by at least 50%. Six patients (31%) reported side effects, especially cognitive impairment and weight loss (>5 kg) in two patients. In the further course of treatment, ZNS was discontinued in two of three patients because of cognitive impairment. We conclude that add-on treatment including ZNS and TPM can not be recommended for chronic treatment of epilepsy.
- Subjects
ANTICONVULSANTS; MEDICAL research; TREATMENT of epilepsy; TOPIRAMATE; DRUG side effects; THERAPEUTICS
- Publication
Der Nervenarzt, 2007, Vol 78, Issue 12, p1425
- ISSN
0028-2804
- Publication type
Article
- DOI
10.1007/s00115-007-2333-x