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- Title
Experimental mouse tumour models: what can be learnt about human cancer immunology?
- Authors
Dranoff, Glenn
- Abstract
The recent demonstration that cancer immunotherapy extends patient survival has reinvigorated interest in elucidating the role of immunity in tumour pathogenesis. Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment strategies. To accelerate the translation of these findings into clinical benefits, investigators need to gain a better understanding of the strengths and limitations of mouse model systems as tools for deciphering human antitumour immune responses.
- Subjects
CANCER immunotherapy; LABORATORY mice; INTERFERONS; ANTIGENS; CLINICAL trials
- Publication
Nature Reviews Immunology, 2012, Vol 12, Issue 1, p61
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri3129