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- Title
The role of vitamin D receptor in predentin mineralization and dental repair after injury.
- Authors
Liu, Yudong; Wu, Yinlin; Hu, Xiaodong; Sun, Yu; Zeng, Guojin; Wang, Qinglong; Liu, Shanshan; Sun, Meiqun
- Abstract
Dentin is a permeable and complex tubular composite formed by the mineralization of predentin that mineralization and repair are of considerable clinical interest during dentin homeostasis. The role of Vdr, a receptor of vitamin D, in dentin homeostasis remains unexplored. The aim of the present study was to assess the impact of Vdr on predentin mineralization and dental repair. Vdr-knockout (Vdr−/−) mice models were constructed; histology and immunohistochemistry analyses were conducted for both WT and Vdr−/− mice. The finding revealed a thicker predentin in Vdr−/− mice, characterized by higher expression of biglycan and decorin. A dental injury model was employed to observe tertiary dentin formation in Vdr−/− mice with dental injuries. Results showed that tertiary dentin was harder to form in Vdr−/− mice with dental injury. Over time, heightened pulp invasion was observed at the injury site in Vdr−/− mice. Expression of biglycan and decorin was reduced in the predentin at the injury site in the Vdr−/− mice by immunohistochemistry. Taken together, our results imply that Vdr plays a regulatory role in predentin mineralization and tertiary dentin formation during dentin homeostasis.
- Subjects
VITAMIN D receptors; MINERALIZATION; DENTIN; WOUNDS &; injuries
- Publication
Cell & Tissue Research, 2024, Vol 396, Issue 3, p343
- ISSN
0302-766X
- Publication type
Article
- DOI
10.1007/s00441-024-03886-7