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- Title
Intrapartum antibiotics and childhood asthma and allergic rhinitis: a retrospective cohort study.
- Authors
Richards, M; Ferber, J; Swor, E; Frescholtz, T; Li, D‐K; Darrow, LA
- Abstract
Objective: This study aimed to evaluate the association between intrapartum antibiotics (IABX) and asthma and allergic rhinitis among children by ages 6, 8 and 10 years. Design: Retrospective cohort. Setting and population: Data were collected though Kaiser Permanente Northern California's (KPNC) integrated healthcare system. Children were eligible if they were born in a KPNC hospital between 1997 and 2012 and stayed enrolled through age 6. Methods: Modified Poisson regressions with robust error variances were used to estimate risk ratios for IABX and each outcome at each follow‐up age during two separate time periods: 1997–2004 (n = 91 739) and 2005–2012 (n = 108 314). Main outcome measures: Asthma and allergic rhinitis by ages 6, 8 and 10. Results: The proportion of women receiving IABX increased drastically over the study period (from 4% in 1997 to 49% in 2011), while the incidence of asthma (8%) and allergic rhinitis (6%) stayed relatively stable. In adjusted models, risk ratios for the association between IABX and asthma and allergic rhinitis were largely compatible with the null, with some slightly elevated risk ratios observed. For births from 1997 to 2004, risk ratios for asthma were 1.08 (95% CI 1.00–1.17) at age 6, 1.05 (95% CI 0.97–1.15) at age 8, and 1.08 (95% CI 0.99–1.18) at age 10. For births from 2005 to 2012, risk ratios were 1.00 (95% CI 0.95–1.04) at age 6, 1.07 (95% CI 1.01–1.12) at age 8, and 1.11 (95% CI 1.03–1.20) at age 10. Conclusions: Exposure to intrapartum antibiotics is not a strong predictor of childhood asthma or allergic rhinitis risk. Exposure to intrapartum antibiotics is not a strong predictor of childhood asthma or allergic rhinitis risk. Exposure to intrapartum antibiotics is not a strong predictor of childhood asthma or allergic rhinitis risk. Linked article This article is commented on by RL Goldenberg & EM McClure, pp. 731–732 in this issue. To view this minicommentary visit https://doi.org/10.1111/1471-0528.17016.
- Subjects
CALIFORNIA; ASTHMA in children; ALLERGIC rhinitis; ANTIBIOTICS; COHORT analysis; POISSON regression
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2022, Vol 129, Issue 5, p722
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/1471-0528.16977