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- Title
Chemokine-derived oncolytic peptide induces immunogenic cancer cell death and significantly suppresses tumor growth.
- Authors
Furukawa, Natsuki; Yang, Wendy; Chao, Alex R.; Patil, Akash; Mirando, Adam C.; Pandey, Niranjan B.; Popel, Aleksander S.
- Abstract
Chemokinostatin-1 (CKS1) is a 24-mer peptide originally discovered as an anti-angiogenic peptide derived from the CXCL1 chemokine. Here, we demonstrate that CKS1 acts not only as an anti-angiogenic peptide but also as an oncolytic peptide due to its structural and physical properties. CKS1 induced both necrotic and apoptotic cell death specifically in cancer cells while showing minimal toxicity in non-cancerous cells. Mechanistically, CKS1 disrupted the cell membrane of cancer cells quickly after treatment and activated the apoptotic pathway at later time points. Furthermore, immunogenic molecules were released from CKS1-treated cells, indicating that CKS1 induces immunogenic cell death. CKS1 effectively suppressed tumor growth in vivo. Collectively, these data demonstrate that CKS1 functions as an oncolytic peptide and has a therapeutic potential to treat cancer.
- Subjects
PEPTIDES; CANCER cells; CELL death; TUMOR growth; CHEMOKINE receptors
- Publication
Cell Death Discovery, 2024, Vol 10, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-024-01932-5