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- Title
The potential role of hydrogen sulfide in cancer cell apoptosis.
- Authors
Gao, Wei; Liu, Ya-Fang; Zhang, Yan-Xia; Wang, Yan; Jin, Yu-Qing; Yuan, Hang; Liang, Xiao-Yi; Ji, Xin-Ying; Jiang, Qi-Ying; Wu, Dong-Dong
- Abstract
For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent studies have found that H2S is the third gaseous signaling molecule which plays a vital role in physiological and pathological conditions. Currently, a large number of studies have shown that H2S mediates apoptosis through multiple signaling pathways to participate in cancer occurrence and development, for example, PI3K/Akt/mTOR and MAPK signaling pathways. Therefore, the regulation of the production and metabolism of H2S to mediate the apoptotic process of cancer cells may improve the effectiveness of cancer treatment. In this review, the role and mechanism of H2S in cancer cell apoptosis in mammals are summarized.
- Subjects
HYDROGEN sulfide; CANCER cells; APOPTOSIS; METABOLIC regulation; CARCINOGENESIS; CELLULAR signal transduction
- Publication
Cell Death Discovery, 2024, Vol 10, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-024-01868-w