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- Title
The effect of Hangeshashinto on Oral Mucositis Caused by Induction Chemotherapy in Patients with Head and Neck Cancer.
- Authors
Kenkichiro Taira; Kazunori Fujiwara; Takahiro Fukuhara; Satoshi Koyama; Hiromi Takeuchi
- Abstract
Background Oral mucositis (OM) is a side effect of chemotherapy in head and neck cancer. Severe OM often has a large impact on quality of life. Therefore, the treatment of OM during chemotherapy is very important. It was recently reported that Hangeshashinto (TJ-14), a Japanese traditional medicine (Kampo), is effective for OM caused by fluorinated pyrimidinebased agents used in colon cancer. We investigated the efficacy of TJ-14 for OM. Methods We enrolled patients with head and neck cancer who were treated with induction chemotherapy between September 2014 and March 2016. In this double-blind trial, patients were randomly assigned to the TJ-14 group or placebo group. Patients were instructed to dissolve 2.5 g of TJ-14 or placebo in 100 ml of drinking water, rinse their mouths with the solution for 30 s and then spit it out. They were not allowed to eat anything for 30 minutes before or after using the mouthwash. Results The incidence of = grade 2 OM was 37.5% (three patients) in the TJ-14 group and 50.0% (four patients) in the placebo group, with no significant difference between the two groups. The mean day of onset was 9.7 in the TJ-14 group and 6.7 in the placebo group. The mean duration of = grade 2 OM was 1.3 days in the TJ-14 group and 3.7 days in the placebo group. Thus TJ-14 significantly reduced the duration of = grade 2 OM. Conclusion Treatment of OM with TJ-14 was associated with a statistically significant reduction in the duration of = grade 2 OM compared to placebo. Gargling with TJ-14 is a safe and effective method of administering the drug to patients with head and neck cancer.
- Subjects
HEAD &; neck cancer treatment; CANCER chemotherapy; TRADITIONAL medicine; DRINKING water; DRUG administration
- Publication
Yonago Acta Medica, 2020, Vol 63, Issue 3, p183
- ISSN
0513-5710
- Publication type
Article
- DOI
10.33160/yam.2020.08.007