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- Title
Exclusion of Transforming Growth Factor-b1 as a Candidate Gene for Myopia in the Japanese.
- Authors
Takahiko Hayashi; Hidetoshi Inoko; Shigeaki Ohno; Nobuhisa Mizuki
- Abstract
Abstract Purpose To determine whether single-nucleotide polymorphisms (SNPs) within the transforming growth factor-ß1 (TGF-ß1) gene are associated with high myopia in Japanese. Previous studies have indicated that the gene expression products, regulators of theTGF-ß1gene, are involved in high myopia. Methods Genomic DNA samples were obtained from 330 Japanese patients with high myopia and 330 Japanese controls without high myopia who were chosen at random. SNPs were genotyped by the TaqMan system, using primer extension and polymerase chain reaction amplification. Results Ten SNPs were identified in the high-myopia patients and controls, with four of the ten SNPs having nonsynonymous changes. However, no statistical differences in the SNPs were detected between the high-myopia cases and the controls. Conclusions Sequence variants of theTGF-ß1gene were not associated significantly with high myopia, and further studies are needed to identify which genes are responsible for high myopia.Jpn J Ophthalmol2007;51:96–99 Japanese Ophthalmological Society 2007
- Subjects
GENETIC polymorphisms; NUCLEOTIDES; TRANSFORMING growth factors; MYOPIA; GENE expression; DNA
- Publication
Japanese Journal of Ophthalmology, 2007, Vol 51, Issue 2, p96
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-006-0417-y