We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Young Blood Environment Decreases Aging of Senile Mice Kidneys.
- Authors
Qi Huang; Yichun Ning; Dong Liu; Ying Zhang; Diangeng Li; Yinping Zhang; Zhong Yin; Bo Fu; Guangyan Cai; Xuefeng Sun; Xiangmei Chen; Huang, Qi; Ning, Yichun; Liu, Dong; Zhang, Ying; Li, Diangeng; Zhang, Yinping; Yin, Zhong; Fu, Bo; Cai, Guangyan
- Abstract
Whether changes in internal body environment affect kidney aging remains unclear. Specifically, it is unknown whether transplanted kidneys from older donors recover from tissue damage after placement in younger recipients. In this study, a parabiosis animal model was established to investigate the effects of a young internal body environment on aged kidneys. The animals were divided into six groups: young (Ycon) and old control (Ocon) groups, isochronic youth-youth group (Y-IP), elderly-elderly group (O-IP), and heterochronic youth (Y-HP) and elderly (O-HP) groups. After parabiosis, tubule and interstitial tissue scores in the O-HP group were significantly lower than in the Ocon and O-IP groups. The expression of aging-related protein p16 and SA-β-gal in the O-HP group was significantly reduced compared with the Ocon and O-IP groups. Autophagy factors Atg5 and LC3BII were significantly upregulated, whereas the expression of the autophagic degradation marker (P62) was significantly downregulated in the O-HP group compared with the Ocon and O-IP groups. With the same comparison, the positive cells of TUNEL staining and the expression of IL-6 and IL-1β were significantly reduced, whereas the total/cleaved caspase-3 and total/pNF-κB were significantly increased in the O-HP group. The results demonstrated that a young blood environment significantly reduces kidney aging. These findings provide new evidence supporting an increase in the upper age limit for human kidney transplantation donors.
- Subjects
CARDIOVASCULAR diseases; ORGANS (Anatomy); DIABETIC nephropathies; SENILE dementia; HYPERTENSION
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2018, Vol 73, Issue 4, p421
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glx183