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- Title
Piroglutamil Peptidlerin Farelerde Skopolaminle Oluşturulmuş Öğrenme-Bellek Bozukluğu Üzerine Etkisi.
- Authors
Uygun, İbrahim; Bozkurt, Şeyma Nur Başarır; Al Yousef, Mohammad; Mohammed, Mohammed Omer Khalid; Tanyeri, Pelin; Akar, Füruzan; Erden, Faruk; Mutlu, Oğuz
- Abstract
Introduction Adipokinetic hormone plays role in sugar and lipid mobilization of insects. Adipokinetic hormone exerted improving effects on learning and memory in schizophrenia and olfactory bulbectomy model of rats. It is hypothesized that metabolites of adipokinetic hormone, including pyroglutamyl peptides, pass the blood-brain barrier after the intraperitoneal administration of adipokinetic hormone to rats. The aim of this study is to investigate effects of pyroglutamyl peptides on learning and memory both in naive mice and in scopolamine-induced memory deterioration. Materials and Methods In this study, we used modified elevated plus maze (mEPM) and passive avoidance tests to examine learning and memory functions. We used scopolamine (1 mg/kg) and pyroglutamic acid-valine (pGlu-Val; 10 and 20 mg/kg), pyroglutamic acid-leucine (pGlu-Leu; 10 and 20 mg/kg) as pyroglutamyl peptides. Results In mEPM test there was no significant effect of dipeptides on transfer latency-2 in naive mice. Scopolamine partially increased transfer latency-2 in second trial and this effect was significantly reversed by pGlu-Leu (10 ve 20 mg/kg; p=0,0064; p=0,0055 respectively) although pGlu-Val had no effect. In passive avoidance test none of the dipeptides reversed retention latency of scopolamine group. Conclusion We found that pyroglutamyl peptides had no effect on learning and memory in naive mice. pGlu-Leu had improving effect on scopolamine induced learning impairment in the mEPM test while both of the peptides had no effect on scopolamine induced memory impairment in the passive avoidance test.
- Publication
Sakarya Tıp Dergisi, 2023, Vol 13, Issue 3, p446
- ISSN
2146-2585
- Publication type
Article
- DOI
10.31832/smj.1239798