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- Title
Switches in gene expression including microRNA and a large number of distinct mRNAs.
- Authors
Zhdanov, V. P.
- Abstract
In eukaryotic cells, the kinetics of gene expression depends on the interplay of messenger RNAs (mRNAs), proteins, and nonprotein coding RNAs, or, more specifically, microRNAs. Some microRNAs may target hundreds of mRNAs. To describe this case, the author proposes a kinetic model implying that the microRNA synthesis is suppressed by the protein produced via the translation of one of the target mRNAs. With physically reasonable model parameters, the model predicts bistability or, in other words, switches in the expression of hundreds of genes.
- Subjects
GENE expression; MESSENGER RNA; EUKARYOTIC cells; NON-coding RNA; GENETIC regulation
- Publication
JETP Letters, 2008, Vol 88, Issue 7, p466
- ISSN
0021-3640
- Publication type
Article
- DOI
10.1134/S0021364008190120