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- Title
他克莫司乳膏联合治疗白癜风的疗效评价.
- Authors
卢宏俐; 胡倩倩; 何华萍; 康俞莉; 张立
- Abstract
Objective: To compare the efficacy of autologous epidermal grafting combined with tacrolimus and conventional autologous epidermal grafting for vitiligo. Methods: The repigmentation time and efficacy of autologous epidermal grafting combined with tacrolimus group and traditional autologous epidermal grafting in total 90 stable vitiligo patients were retrospectively studied. Results: The epidermal transplantation combined with tacrolimus group had significantly shorter repigmentation time than the single epidermal graft group (P<0.05). The efficacy in the epidermal grafting combined with tacrolimus showed significantly higher at 1 month and 3 months after treatment than that of the single epidermal graft group (P< 0.05). The efficacy in different sites are varying, of which the neck is the best; the limbs are the worst. The combination therapy of tacrolimus and autologous epidermal grafting can improve the repigmentation at the site of limbs. The efficacy of autologous epidermal grafting combined with tacrolimus was significantly higher in segmental and localized vitiligo compared with those in single autologous epidermal grafting (P<0.05). However, tacrolimus combination therapy can improve the efficacy of sporadic and acral vitiligo with no statistical difference (P>0.05) . There was no significant difference in the gender between the two groups (P>0.05). In autologous epidermal grafting group combined with tacrolimus group and the single epidermal graft group, the efficacy in male was higher than that in female with no significant difference. Conclusion: Autologous epidermal grafting combined with tacrolimus is better for repigmentation than conventional autologous epidermal grafting.
- Subjects
AUTOTRANSPLANTATION; TACROLIMUS; VITILIGO; TRANSPLANTATION of organs, tissues, etc.; NECK
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 2, p273
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.02.014