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- Title
Effect of Chronic Heart Rate Reduction by If Current Inhibitor Ivabradine on Left Ventricular Remodeling and Systolic Performance in Middle-Aged Rats With Postmyocardial Infarction Heart Failure.
- Authors
Dedkov, Eduard I.; Bogatyryov, Yevgen; McCooey, Daniela Scaldaferri; Christensen, Lance P.; Weiss, Robert M.; Tomanek, Robert J.
- Abstract
The article focuses on a study which determines whether long-term inhibitor ivabradine (IVA) therapy can sustainably maintain the beneficial impact of pure heart rate reduction on left ventricular (LV) remodeling and systolic performance in middle-aged rats with heart failure (HF) due to a large myocardial infarction (MI). Topics discussed include the echocardiographic examination done on the rats and the structural parameters of the LV in sham, untreated and ivabradine-treated post-MI rats.
- Subjects
IVABRADINE; IF inhibitors; VENTRICULAR remodeling; MYOCARDIAL infarction complications; HEART beat; THERAPEUTICS
- Publication
Journal of Cardiovascular Pharmacology & Therapeutics, 2015, Vol 20, Issue 3, p299
- ISSN
1074-2484
- Publication type
Article
- DOI
10.1177/1074248414553231