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- Title
Safety and Therapeutic Effect of Intrathecal Administration of Umbilical Cord Mesenchymal Stemcells in Neurological Disorders.
- Authors
YANG Hua-qiang; ZHANG Rong-huan; LI Hong; HU Ming-jun; LI Yu-ling; QIN Jun; BAO Hong-xia; LV Xiao-juan
- Abstract
Objective: Advances in stem cell biology have generated intense interest in the prospect of transplanting stem cells into the nervous system for the treatment of refractory neurological diseases. Here we investigate the safety of intrathecal administration of umbilical cord mesenchymal stem cells by lumbar puncture and analyze the technical difficulties and short and long-term effects of umbilical cord mesenchymal stem cells transplantation in various neurological conditions. Methods: Eighty-eight patients underwent subarachnoid placement of umbilical cord mesenchymal stem cells between December 2008 and May 2011 in the affiliated Ren Ming hospital of Hubei University of Medicine. Technical difficulties in the form of localization of subarachnoid space, number of attempts, and postprocedural complications were evaluated. Functional evaluation was done with Hauser Ambulation Index by the stem cell transplant team on a regular basis. All patients were followed up for more than one year after the treatment. Clinical symptoms and related biochemical index and photographic examinations were observed regularly. Results: Of 88 patients, we encountered technical difficulties in 20patients (23%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. In 18 (20.5%) patients, side effects were observed (headache, low-grade fever, low back pain and lower limb pain), which resolved with symptomatic treatment within48 hours. On follow-up one year, functional indices improved in 50 (56.8%) patients, including 15 patients with spinal cord injury, 10 patients with cerebral palsy, 10 patients with post-traumatic brain syndrome, 5 patients with post-brain infarction syndrome, 5 patients with spinocerebellar ataxias, and 5 patients with motor neuron disease. Conclusion: Intrathecal administration of umbilical cord mesenchymal stem cells is safe and effective with no long-term adverse effects in neurological disorders. The encouraging results provide compelling evidence to support the concept that in patients with profound neurological defects and inefficient conventional cure, there is a promise of restoration of lost tissue and improvement of function. These data support expanded double blind, placebo-controlled studies for this treatment modality.
- Subjects
STEM cell treatment; THERAPEUTICS; NEUROLOGICAL disorders
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 15, p2913
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.15.031