We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inhibition of MARK2 inhibits ovarian cancer cell proliferation by regulating PI3K/AKT/p53 axis.
- Authors
Weijie Xiong; Hongyu Xu; Yuntao Wang; Ying Wang; Lang He
- Abstract
Ovarian cancer (OC) is the 3rd most common type of the gynecological malignancy. Although current treatment strategies have greatly improved, there is still a need to develop new biomarkers for OC diagnosis and treatment. Microtubule affinity regulated kinase 2 (MARK2) is a kinase involved in the progression of multiple tumors. However, whether abnormal expression of MARK2 is associated with OC progression needs further analysis. We here revealed its role in OC. We found high expression of MARK2 in OC. Knockdown of MARK2 inhibited proliferation of OC cells, stimulated apoptosis of OC cells, and restrained glucose metabolism of OC cells. Furthermore, MARK2 regulated phosphatidylinositol 3-kinase/PKB (protein kinase B)/tumor suppressor protein 53 (PI3K/AKT/p53) axis in OC, therefore affecting the progression of OC. In summary, MARK2 knockdown suppressed cell proliferation by regulating PI3K/AKT/p53 axis.
- Subjects
OVARIAN cancer; MICROTUBULE-associated protein kinase; APOPTOSIS; GLUCOSE metabolism; TUMOR suppressor proteins
- Publication
European Journal of Gynaecological Oncology, 2023, Vol 44, Issue 5, p132
- ISSN
0392-2936
- Publication type
Article
- DOI
10.22514/ejgo.2023.088