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- Title
Stimulant Treatment and Potential Adverse Outcomes in Pediatric Populations With Bipolar Disorder: A Systematic Review of the Literature.
- Authors
O'Connor, Hannah; Hutt Vater, Chloe; DiSalvo, Maura; Faraone, Stephen V.; Wozniak, Janet
- Abstract
Objective: To explore outcomes of stimulant treatment for ADHD in pediatric populations with particular attention to bipolar disorder (BPD). Method: We conducted a literature search of PubMed articles published prior to August 25, 2022 that focused on BPD, mania, and psychosis prior to, or as result of, stimulant treatment. We excluded studies: (1) unrelated to stimulants, (2) general stimulant research, (3) articles older than 40 years, (4) study protocols, or (5) case reports. Results: A total of 11 articles met all inclusion/exclusion criteria. Some reports found stimulant treatment safe and well-tolerated in children with comorbid BPD and ADHD. Others found evidence of treatment-emergent mania (TEM), discontinuation, and other adverse events with stimulant treatment. Conclusion: Poor outcomes associated with stimulant treatment in pediatric populations with BPD necessitate work to identify patients at risk of serious stimulant-related adverse events. Our results were limited by automated search filters and a pediatric, primarily male sample.
- Subjects
CHILD patients; BIPOLAR disorder; STIMULANTS; PEDIATRIC therapy; RESEARCH protocols
- Publication
Journal of Attention Disorders, 2024, Vol 28, Issue 5, p740
- ISSN
1087-0547
- Publication type
Article
- DOI
10.1177/10870547231218045