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- Title
Clinical Trial Participation and COVID-19: a Descriptive Analysis from the American Heart Association's Get With The Guidelines Registry.
- Authors
Shah, Kevin S.; Reyes-Miranda, Adriana E.; Bradley, Steven M.; Breathett, Khadijah; Das, Sandeep R.; Gluckman, Ty J.; Gupta, Divya; Leung, Daniel T.; Mutharasan, R. Kannan; Peterson, Pamela N.; Spivak, Emily S.; Shah, Rashmee U.
- Abstract
As COVID-19 cases begin to decrease in the USA, learning from the pandemic experience will provide insights regarding disparities of care delivery. We sought to determine if specific populations hospitalized with COVID-19 are equally likely to be enrolled in clinical trials. We examined patients hospitalized with COVID-19 at centers participating in the American Heart Association's COVID-19 CVD Registry. The primary outcome was odds of enrollment in a clinical trial, according to sex, race, and ethnicity. Among 14,397 adults hospitalized with COVID-19, 9.5% (n = 1,377) were enrolled in a clinical trial. The proportion of enrolled patients was the lowest for Black patients (8%); in multivariable analysis, female and Black patients were less likely to be enrolled in a clinical trial related to COVID-19 compared to men and other racial groups, respectively. Determination of specific reasons for the disparities in trial participation related to COVID-19 in these populations should be further investigated.
- Subjects
COVID-19; CLINICAL trials; PATIENT participation; CONFIDENCE intervals; RESEARCH methodology; MULTIVARIATE analysis; RACE; SEX distribution; HOSPITAL care; RESEARCH funding; DESCRIPTIVE statistics; DATA analysis software; ODDS ratio
- Publication
Journal of Racial & Ethnic Health Disparities, 2023, Vol 10, Issue 2, p892
- ISSN
2197-3792
- Publication type
Article
- DOI
10.1007/s40615-022-01277-8