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- Title
Synthesis, Characterization, and Anticancer Activity of Some Thiazole and Imidazolidine Derivatives Containing Pyridine Moiety.
- Authors
Al-Saleem, M. S.; El-Shenawy, A. I.; Abd El-Moneim, M.; El-Sayed, E. H.
- Abstract
5-Phenyl-2-[(6-acetylpyridine-2-ylethylidene)hydrazino]thiazole 4 and 1-[(6-acetylpyrid-ine-2-ylethylidene)amino]-2-thioxoimidazolidine-4-one 6 are synthesized by cyclization of 1-[1-(6-acetylpyridin-2- yl)ethylidene]thiosemicarbazide 2 with phenacyl(ω)bromide or ethyl chloroacetate in the presence of fused sodium acetate. Reaction of compounds 2, 4, and 6 with acetic anhydride gives N-triacetyl derivative 3 and N-acetyl derivatives 5 and 7. Treatment of compound 6 with 4-methoxy benzaldehyde yields the corresponding carbanol derivative 8. Structures of the synthesized heterocyclic compounds are characterized by EI-MS and NMR spectroscopy. Antitumor activity of compounds 4, 6, 8, and 9 is evaluated against human breast carcinoma cell line (MCF-7).
- Subjects
ANTINEOPLASTIC agents; THIAZOLE derivatives; IMIDAZOLIDINES; HETEROCYCLIC compounds; PYRIDINE
- Publication
Russian Journal of General Chemistry, 2018, Vol 88, Issue 12, p2675
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363218120320