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- Title
The Comparison of the Effects of Combined Therapy Using Clozapine and Risperidone with the Effects of Using Clozapine and ECT in Patients with Clozapine Treatment-Resistant Schizophrenia.
- Authors
Fazaelipour, Zahra; Bidaki, Reza; Hosseini, Fatemeh; Yasini, Mojtaba
- Abstract
Background and objective: In spite of the effectiveness of antipsychotic medications in treating patients with schizophrenia, the presence of resistance to medications in these patients poses the need for new meditational combinations to enhance the treatment of them. This study has been conducted aimed at making a comparison between the effects of combined therapy using clozapine and risperidone with the effects of using clozapine and ECT in patients with schizophrenia who had referred to the comprehensive psychiatric center in the city of Taft, in 2017. Martial and Method: In this clinical trial study, 30 patients with schizophrenia were randomly selected to receive the co-administration of clozapine and risperidone (15 patients) and the combination therapy of clozapine and ECT (15 patients). Before the intervention, both groups completed the questionnaire of the Positive and Negative Symptoms of Schizophrenia (PANSS). Both groups received the intervention for 6 sessions, 3 times a week. After the intervention (6 weeks later), both groups completed the questionnaire of the Positive and Negative Symptoms of Schizophrenia (PANSS) once more. The data obtained from the SPSS software, statistical samples, the chi-square test, and the paired t-test were analyzed. Results: The comparison of the indicators of the questionnaire PANSS before and after treatment in patients with the combined therapy of clozapine and risperidone with the patients with the combined therapy of clozapine and ECT showed that the factors of negative symptoms, disruption, and excitement were remarkably lower in the group that experienced the combined therapy of clozapine and ECT (P<.0.05). The indicators of positive symptoms, anxiety and depression were significantly weaker in the group that experienced clozapine and risperidone (P<.0.05). The decrease in the scores of the questionnaire PANSS was remarkably higher in the group that experienced clozapine and ECT (P <0.05). Conclusion: The results of this study indicated the effects of both the combined therapy of clozapine and risperidone as well as clozapine and ECT on the improvement of the positive and negative symptoms of schizophrenia. Therefore, both treatments have been effective in improving the positive and negative symptoms of patients with schizophrenia. However, considering the more significant reduction in the score of the questionnaire PANSS in the group with the combined therapy of clozapine and ECT, more studies are required to be done on this type of treatment.
- Subjects
MARTIAL, d. ca. 102; CLOZAPINE; RISPERIDONE; ANTIPSYCHOTIC agents; SCHIZOPHRENIA; GROUP psychotherapy
- Publication
Iranian Journal of Psychiatry & Behavioral Sciences / Progress in Psychiatry & Behavioral Sciences, 2018, p162
- ISSN
1735-8639
- Publication type
Article