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- Title
Directional Coupler Biosensor with Molecularly Imprinted Polymer.
- Authors
Ken Uchiyamada; Kyohei Okubo; Kiyoshi Asakawa; Yuri Kamon; Yukiya Kitayama; Toshifumi Takeuchi; Hiroaki Suzuki
- Abstract
A microfabricated directional coupler (DC) was used for the label-free, real-time detection of proteins. As an alternative to biomolecules such as antibodies, molecularly imprinted polymer (MIP) was used. With human serum albumin (HSA) as a model analyte, distinct responses were observed. On the other hand, the sensor did not respond to bovine serum albumin (BSA). Also, with a nonimprinted polymer (NIP), no responses were observed for HSA. The MIP could be regenerated, and responses of the same sensor after three cycles of measurement and regeneration gave similar values.
- Subjects
DIRECTIONAL couplers; IMPRINTED polymers; POLYMERIZATION; SERUM albumin; BIOMOLECULE analysis
- Publication
Sensors & Materials, 2018, Vol 30, Issue 5, Part 1, p1009
- ISSN
0914-4935
- Publication type
Article
- DOI
10.18494/SAM.2018.1815