We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Highly Efficient Regioselective Acylation of Dihydromyricetin Catalyzed by Lipase in Nonaqueous Solvents.
- Authors
Zhu, Song; Du, Baoshuang; Huang, Dejian; Xia, Yongmei; Chen, Shangwei; Li, Yue
- Abstract
This study aimed to explore the enzymatic acylation of dihydromyricetin (DHM) to synthesized DHM derivatives with a different substituted carbon chain to improve its liposolubility. In the presence of Lipozyme TL IM, DHM was butyrylated in a 96.28% conversion in methyl tert-butyl ether under the optimized conditions (molar ratio of DHM to vinyl butyrate, 1:20; lipase dosage, 0.4 U/mg DHM; temperature, 50 °C; stirrer speed, 200 rpm; reaction time, 72 h). Liquid chromatography-mass spectrometry (LC-MS) and nuclear magnetic resonance (NMR) spectroscopy revealed that two acylation products were formed; these were 7-O-acyl-DHM and 3-O-acyl-DHM. In addition, the liposolubility of the DHM derivatives increased with the increase in the substituted carbon chain length; their antioxidant activities were higher than that of DHM in the lecithin peroxidation system, and C8-DHM had a better effect. Therefore, enzymatic acylation broadens the application of DHM in a lipid system in the food field.
- Subjects
NONAQUEOUS solvents; ACYLATION; LIQUID chromatography-mass spectrometry; BUTYL methyl ether; LIPASES; REGIOSELECTIVITY (Chemistry); SOLVENTS; KINETIC resolution
- Publication
Processes, 2022, Vol 10, Issue 7, pN.PAG
- ISSN
2227-9717
- Publication type
Article
- DOI
10.3390/pr10071368