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- Title
Local and Systemic Effects of Porphyromonas gingivalis Infection.
- Authors
Chen, William A.; Dou, Yuetan; Fletcher, Hansel M.; Boskovic, Danilo S.
- Abstract
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors.
- Subjects
PORPHYROMONAS gingivalis infections; PORPHYROMONAS gingivalis; INFLAMMATION; ESSENTIAL nutrients; GRAM-negative bacteria; IMMUNE response
- Publication
Microorganisms, 2023, Vol 11, Issue 2, p470
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms11020470