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- Title
Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats.
- Authors
Li, Hong-Bao; Qin, Da-Nian; Cheng, Kang; Su, Qing; Miao, Yu-Wang; Guo, Jing; Zhang, Meng; Zhu, Guo-Qing; Kang, Yu-Ming
- Abstract
Salusin β is a multifunctional bioactive peptide and is considered as a promising candidate biomarker for predicting atherosclerotic cardiovascular diseases. The present study was designed to investigate the roles and mechanisms of salusin β in the paraventricular nucleus (PVN) in attenuating hypertension and hypothalamic inflammation and whether central salusin β blockade has protective effects in essential hypertension. Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were used in this study. The rats were chronic PVN infusion either specific salusin β blocker, antisalusin β IgG (SIgG), or control IgG (CIgG) for 2 weeks. Hypertensive rats had significantly increased salusin β expression compared with normotensive rats. Central blockade of salusin β attenuated hypertension, reduced circulating norepinephrine (NE) levels, and improved cardiac hypertrophy and function in hypertensive rats. Salusin β blockade significantly reduced proinflammatory cytokines (PICs), nuclear factor-kappa B (NF-κB) activity, reactive oxygen species (ROS) levels, and altered renin-angiotensin system (RAS) components in the PVN of hypertensive rats. These findings suggest that the beneficial effects of salusin β blockade in essential hypertension are possibly due to down-regulate of inflammatory molecules and ROS in the PVN.
- Subjects
HYPERTENSION; LABORATORY rats; HYPOTHALAMUS; INFLAMMATION; HYPERTROPHY; CYTOKINES
- Publication
Scientific Reports, 2015, p11162
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep11162