We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hyaluronic Acid-Coated Bovine Milk Exosomes for Achieving Tumor-Specific Intracellular Delivery of miRNA-204.
- Authors
Li, Dan; Gong, Liang; Lin, Han; Yao, Surui; Yin, Yuan; Zhou, Zhifang; Shi, Jie; Wu, Zhimeng; Huang, Zhaohui
- Abstract
Cell type-specific drug delivery is a straightforward strategy to achieve targeted cancer therapy and reduce side effects. Hyaluronic acid (HA), an U.S. Food and Drug Administration (FDA)-approved biocompatible carbohydrate polymer, has been extensively employed as a targeting ligand for a drug delivery system due to its natural ability to bind to tumor cells overexpressing cluster of differentiation 44 (CD44) receptors. Here, we report the preparation and antitumor efficacy of HA-coated bovine milk exosomes (HA-mExo) for tumor-specific delivery of microRNA-204-5p mimics (miR-204). The exosome-based delivery formulation was prepared with miR-204 encapsulated inside the lumen and HA displayed outside the membrane. The resultant formulation of HA-mExo-miR204 was able to specifically target CD44-positive cancer cells, with a concomitant increase in the intracellular uptake of miR-204. Compared to the uncoated mExo-miR204 formulation, HA-mExo-miR204 showed significantly increased antitumor efficacy both in vitro and in vivo. Importantly, HA-mExo-miR204 showed excellent biocompatibility and did not cause significant systemic toxicity. Given that both HA and bovine milk exosomes are low-cost and highly accessible biogenic materials with broad biomedical applications, HA-decorated bovine milk exosomes can be proven to be a practical drug delivery system of RNA drugs for targeted cancer therapy.
- Subjects
UNITED States. Food &; Drug Administration; DRUG delivery systems; BOS; MILK; HYALURONIC acid; EXOSOMES; BIOMEDICAL materials
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 19, p3065
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11193065