We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Novel Classification Model for Lower-Grade Glioma Patients Based on Pyroptosis-Related Genes.
- Authors
Shen, Yusheng; Chi, Hao; Xu, Ke; Li, Yandong; Yin, Xisheng; Chen, Shi; Yang, Qian; He, Miao; Zhu, Guohua; Li, Xiaosong
- Abstract
Recent studies demonstrated that pyroptosis plays a crucial role in shaping the tumor-immune microenvironment. However, the influence of pyroptosis on lower-grade glioma regarding immunotherapy and targeted therapy is still unknown. This study analyzed the variations of 33 pyroptosis-related genes in lower-grade glioma and normal tissues. Our study found considerable genetic and expression alterations in heterogeneity among lower-grade gliomas and normal brain tissues. There are two pyroptosis phenotypes in lower-grade glioma, and they exhibited differences in cell infiltration characteristics and clinical characters. Then, a PyroScore model using the lasso-cox method was constructed to measure the level of pyroptosis in each patient. PyroScore can refine the lower-grade glioma patients with a stratified prognosis and a distinct tumor immune microenvironment. Pyscore may also be an effective factor in predicting potential therapeutic benefits. In silico analysis showed that patients with a lower PyroScore are expected to be more sensitive to targeted therapy and immunotherapy. These findings may enhance our understanding of pyroptosis in lower-grade glioma and might help optimize risk stratification for the survival and personalized management of lower-grade glioma patients.
- Subjects
GLIOMAS; GENE expression; PYROPTOSIS; TUMOR microenvironment; GENES
- Publication
Brain Sciences (2076-3425), 2022, Vol 12, Issue 6, p700
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci12060700