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- Title
Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children.
- Authors
Hyun Hee Kim; Mi Hae Chung; Joong Hyun Bin; Kyoung Soon Cho; Juyoung Lee; Jin-Soon Suh
- Abstract
Background: Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. Methods: In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sexmatched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. Results: The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P <0.001). The area under the ROC curve for detecting UTI was 0.88 for the urinary YKL-40/Cr ratio, 0.86 for pyuria, and 0.71 for positive nitrite on urinalysis. We applied a cut-off value of 125.23 pg/mg to urinary YKL-40/Cr for detecting UTI. Eight of nine children in the control group with pyuria had urinary YKL-40/Cr levels lower than 125.23 pg/mg, and the one child in the UTI group without pyuria or positive nitrite had a urinary YKL-40/Cr level greater than 125.23 pg/mg. Conclusions: Determining the levels of urinary YKL-40/Cr may help identify true cases of UTI in febrile young children, especially when they have pyuria but not nitrite, or have neither pyuria nor nitrite in the urine.
- Subjects
URINARY tract infections in children; BIOMARKERS; CREATININE; URINALYSIS; NITRITES
- Publication
Annals of Laboratory Medicine, 2018, Vol 38, Issue 1, p39
- ISSN
2234-3806
- Publication type
Article
- DOI
10.3343/alm.2018.38.1.39