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- Title
Prevalence of zinc transporter 8 antibodies in gestational diabetes mellitus.
- Authors
Dereke, J.; Nilsson, C.; Landin-Olsson, M.; Hillman, M.
- Abstract
Diabet. Med. 29, e436-e439 (2012) Abstract Aims Gestational diabetes mellitus affects approximately 7% of all pregnant women. Some of these women develop autoantibodies that are generally characteristic of Type 1 diabetes. Autoantibodies targeting glutamic acid decarboxylase and tyrosine phosphatase-like protein are the most frequently reported. A recently identified autoantigen in Type 1 diabetes is zinc transporter 8. Some reports suggest that the frequency of zinc transporter 8 antibodies is as high as glutamic acid decarboxylase antibodies in Type 1 diabetes and thus a good diagnostic marker for autoimmune diabetes. There are currently no reports of zinc transporter 8 antibodies in gestational diabetes. The aim of this pilot study was to investigate the frequency of zinc transporter 8 antibodies in patients at clinical onset of gestational diabetes mellitus. Methods Subjects included in this pilot study were all diagnosed with gestational diabetes at Skåne University Hospital, Lund, Sweden, 2009-2010 ( n = 193). Sera samples were analysed for antibodies using a commercial enzyme-linked immunosorbent assay according to the manufacturers' instructions. Results We found that 19/193 patients with gestational diabetes, diagnosed in 2009-2010, were positive for at least one autoantibody. Glutamic acid decarboxylase was the most common single autoantibody (52.6%; 10/19), followed by zinc transporter 8 (21.1%; 4/19) and tyrosine phosphatase -like protein (15.8%; 3/19). Combinations of two or more antibodies were rare (10.5%; 2/19). Conclusions In this study, we found that zinc transporter 8 added 2.1% (4/193) of autoantibody positivity in women with gestational diabetes who were negative for glutamic acid decarboxylase and tyrosine phosphatase -like protein antibodies. Glutamic acid decarboxylase was still the most prevalent autoantibody in gestational diabetes, but, as zinc transporter 8 was present even in the absence of glutamic acid decarboxylase, this autoantibody could be an important independent marker of autoimmunity in gestational diabetes.
- Subjects
AUTOANTIBODIES; C-peptide; CARRIER proteins; GESTATIONAL diabetes; GLUCOSE tolerance tests; IMMUNOGLOBULINS; EVALUATION of medical care; ZINC; DESCRIPTIVE statistics; DIAGNOSIS
- Publication
Diabetic Medicine, 2012, Vol 29, Issue 12, pe436
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2012.03766.x