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- Title
Histone Hi of Saccharomyces cerevisiae Inhibits Transcriptional Silencing.
- Authors
Veron, Marie; Yanfei Zou; Qun Yu; Xin Bi; Selmi, Abdelkader; Gilson, Eric; Defossez, Pierre-Antoine
- Abstract
Eukaryotic genomes contain euchromatic regions, which are transcriptionally active, and heterochromatic regions, which are repressed. These domains are separated by ‘barrier elementsβ: DNA sequences that protect euchromatic regions from encroachment by neighboring heterochromatin. To identify proteins that play a role in the function of barrier elements we have carried out a screen in S. cerevisiae. We recovered the gene HHO1, which encodes the yeast ortholog of histone Hi, as a high-copy modifier of barrier activity. Histone HI is a linker histone that binds the outside of nucleosomes and modifies chromatin dynamics. Here we show that Hho1p reinforces the action of several types of barrier elements, and also inhibits silencing on its own.
- Subjects
GENE silencing; RESPONSE inhibition; HISTONES; GENOMES; GENETIC regulation; SACCHAROMYCES cerevisiae
- Publication
Genetics, 2006, Vol 173, Issue 2, p579
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.105.050195