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- Title
T cells and their products in diabetic kidney disease.
- Authors
Yue Liu; Yaodong Lv; Tingwei Zhang; Tongtong Huang; Yating Lang; Qinghao Sheng; Yingxiao Liu; Zhijuan Kong; Ying Gao; Shangwei Lu; Meilin Yang; Yaqi Luan; Xining Wang; Zhimei Lv
- Abstract
Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and has gradually become a public health problem worldwide. DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression of type 2 diabetic nephropathy and provided a novel perspective of immune-related factors in diabetes. Specific emphasis is placed on the classification of T cells, process of T cell recruitment, function of T cells in the development of diabetic kidney damage, and potential treatments and therapeutic strategies involving T cells.
- Publication
Frontiers in Immunology, 2023, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2023.1084448