We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identification of Distinct Immune Cell \Subsets Associated With Asymptomatic Infection, Disease Severity, and Viral Persistence in COVID-19 Patients.
- Authors
Wang, Xiaorui; Bai, Han; Ma, Junpeng; Qin, Hongyu; Zeng, Qiqi; Hu, Fang; Jiang, Tingting; Mao, Weikang; Zhao, Yang; Chen, Xiaobei; Qi, Xin; Li, Mengyang; Xu, Jiao; Hao, Jingcan; Wang, Yankui; Ding, Xi; Liu, Yuanrui; Huang, Tianlong; Fang, Chao; Ge, Changli
- Abstract
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that were associated with various clinical presentations of COVID-19 using scRNA-seq technology coupled with a deep and comprehensive analysis of unique cell surface markers and differentially expressed genes. We revealed that (TRAV1-2+CD8+)MAIT cells and (NCAM1hiCD160+)NK cells significantly enriched in the asymptomatic subjects whereas (LAG3+CD160+CD8+)NKT cells increased in the symptomatic patients. We also observed that (CD68-CSF1R-IL1BhiCD14+)classical monocytes were positively correlated with the disease severity. Moreover, (CD33-HLA-DMA-CD14+)classical monocytes and (CLEC10A-S100A9lo)pDC were associated with the viral persistence. The GO and KEGG analyses identified enriched pathways related to immune responses, inflammation, and apoptosis. These findings may enhance our understanding of the immunopathogenesis of COVID-19 and help develop novel strategies against SARS-CoV-2 infection.
- Subjects
COVID-19; KILLER cells; SYMPTOMS; CELL analysis; SARS-CoV-2; INFECTION
- Publication
Frontiers in Immunology, 2022, Vol 13, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2022.812514