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- Title
Association of vitamin D and vitamin B<sub>12</sub> with cognitive impairment in elderly aged 80 years or older: a cross‐sectional study.
- Authors
da Rosa, M. I.; Beck, W. O.; Colonetti, T.; Budni, J.; Falchetti, A. C. B.; Colonetti, L.; Coral, A. S.; Meller, F. O.
- Abstract
Background: The present study aimed to assess the association of vitamin D and vitamin B12 with cognitive impairment in elderly people. Methods: The data were obtained from a cross‐sectional study that included individuals aged 80 years or older living in the urban and rural areas of the cities of Siderópolis and Treviso in the state of Santa Catarina, Brazil. In total, 165 elderly people were included in the analysis. The outcome of cognitive decline was assessed by the Mini‐Mental State Examination. Vitamin D and vitamin B12 levels were measured from blood samples. The socio‐demographic, anthropometric and health variables used in the analysis were collected from a questionnaire. Crude and adjusted analyses of the relationship between vitamins D and B12 and cognitive decline were performed using a Poisson regression model. Results: The prevalence of cognitive decline was 35.2%. In the adjusted model, individuals who had vitamin D levels >19 ng mL−1 showed a lower prevalence of cognitive decline (prevalence ratio = 0.59; 95% confidence interval = 0.39–0.87). Those participants who had vitamin B12 levels of ≥496 pg mL−1 had a higher prevalence of cognitive decline (prevalence ratio = 1.90; 95% confidence interval = 1.08–3.36). Conclusions: The present study showed that individuals aged ≥80 years who had vitamin D levels of ≤18 ng mL−1 had a higher prevalence of cognitive decline even after adjustment for potential confounders. In addition, the study demonstrated that vitamin B12 levels of ≥496 pg mL−1 in this population were also a risk factor for cognitive decline. A cross‐sectional analysis does not enable the inference of a cause–effect relationship and additional studies are needed to understand these relationships.
- Subjects
BRAZIL; COGNITION disorders diagnosis; COGNITION disorder risk factors; GERIATRIC assessment; ANTHROPOMETRY; CONFIDENCE intervals; METROPOLITAN areas; POISSON distribution; QUESTIONNAIRES; REGRESSION analysis; RISK assessment; RURAL conditions; VITAMIN B12; VITAMIN D; SOCIOECONOMIC factors; DISEASE prevalence; CROSS-sectional method; OLD age
- Publication
Journal of Human Nutrition & Dietetics, 2019, Vol 32, Issue 4, p518
- ISSN
0952-3871
- Publication type
Article
- DOI
10.1111/jhn.12636