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- Title
Parathyroid hormone is inversely related to endothelin-1 in patients on haemodialysis.
- Authors
Palermo, Alessabdro; Mulè, Giuseppe; Guarneri, Marco; Arsena, Rosalia; Riccobene, Raffaella; Lorito, Maria Carmela; Vaccaro, Francesco; Cerasola, Giovanni; Cottone, Santina
- Abstract
Aim: Parathyroid hormone secretion is mainly influenced by hypocalcaemia, hyperphosphataemia and vitamin D deficiency. However, previous in vitro and in vivo studies showed that endothelin-1 can influence parathyroid hormone secretion. This study was aimed at evaluating this relationship in vivo in uraemic patients. Methods: Parathyroid hormone and endothelin-1 plasma concentrations were measured in 67 haemodialysed patients. Patients with history of cardiovascular diseases and those with parathyroid adenoma were excluded. Results: Plasma levels of endothelin-1 were found to be inversely related to those of parathyroid hormone ( P < 0.04) The multiple regression analysis, carried out considering parathyroid hormone as a dependent variable, and including age, sex, blood pressure, calcium × phosphorus product, and endothelin-1, demonstrated that the independent correlates of parathyroid hormone were endothelin-1 (β = −0.276; P = 0.015), and calcium × phosphorus product (β = 0.417; P < 0.0001). Conclusion: For the first time in vivo, we demonstrated an inverse independent relationship between endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism remains to be elucidated.
- Subjects
PARATHYROID hormone; HEMODIALYSIS patients; ENDOTHELINS; HYPERPARATHYROIDISM; HYPOCALCEMIA; VITAMIN D deficiency
- Publication
Nephrology, 2008, Vol 13, Issue 6, p467
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2008.00972.x