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- Title
Comparison of features and outcomes between HIV‐negative patients with Cryptococcus gattii meningitis and Cryptococcus neoformans meningitis in South China.
- Authors
Su, Xiao‐Hong; Li, Wei‐Peng; Liu, Jun‐Yu; Wang, Yi‐Jie; Liu, Jia; Xu, Xiao‐Feng; Yang, Lu; Xia, Han; Jiang, Ying; Peng, Fu‐Hua
- Abstract
Objectives: The objective of this study is to compare the epidemiologic, clinical, laboratory, and imaging features, and outcomes in patients with Cryptococcus gattii meningitis (CGM) and Cryptococcus neoformans meningitis (CNM). Methods: We performed a retrospective study of HIV‐negative patients with CGM and CNM (2015–2021) distinguished by metagenomic next‐generation sequencing in cerebrospinal fluid in South China. Results: A total of 81 patients (17 CGM, 64 CNM) were enrolled (72.8% male, median age 49 years, range 21–77 years), and CGM patients were younger (median, 43 vs 53 years, p =.005). Of 17 CGM, VGI and VGII accounted for 70.6% and 29.4%, respectively. CGM patients had less underlying diseases (7/17 [41.2%] vs 48/64 [75%], p =.018) and focal neurologic deficit (3/17 [17.6%] vs 35/64 [54.7%], p =.022), had higher intracranial pressure (15/17 [88.2%] vs 25/64 [39.1%], p =.002), more meningeal enhancement (14/17 [82.4%] vs 32/64 [50%], p =.034), less parenchymal involvement (median, 1 vs 3, p =.018), more lung cryptococcomas (6/12 [50%] vs 6/47 [12.8%], p =.014), faster CSF fungal clearance (p =.004), less complications (median, 1 vs 3, p <.001), and more favourable outcomes (16/17 [94.1%] vs 41/64 [64.1%], p =.035). Conclusions: This study demonstrated that species identification helps to guide therapy and predict outcomes.
- Subjects
CHINA; CRYPTOCOCCUS neoformans; CRYPTOCOCCUS; MENINGITIS; NUCLEOTIDE sequencing; CEREBROSPINAL fluid; INTRACRANIAL pressure; LUNGS
- Publication
Mycoses, 2022, Vol 65, Issue 9, p887
- ISSN
0933-7407
- Publication type
Article
- DOI
10.1111/myc.13491