We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cell fusion between tumor cells and macrophages promotes the metastasis of OSCC patient through the activation of the chemokine signaling pathway.
- Authors
Xia, Chengwan; Zhang, Qian; Pu, Yumei; Hu, Qingang; Wang, Yuxin
- Abstract
Background: Tumor metastasis is responsible for the high mortality rate of patients with oral squamous cell carcinoma (OSCC). Although many hypotheses have been proposed to elucidate the mechanism of tumor metastasis, the origin of the metastatic tumor cells remains unclear. In this study, we explored the role of cell fusion in the formation of OSCC metastatic tumor cells. Methods: Murine OSCC tumor cells and macrophages were fused in vitro, and the cell proliferation, migration, and phagocytosis abilities of hybrid cells and parental cells were compared. Subsequently, we compared the transcriptome differences between hybrid and parental cells. Results: Murine OSCC tumor cells and macrophages were successfully fused in vitro. The cytological and molecular experimental results revealed that OSCC tumor cells obtained a migration‐related phenotype after fusion with macrophages, and the migration ability of hybrid cells was related to the activation of the "chemokine signal pathway". Conclusion: After fusion with macrophages, the chemokine signaling pathway in OSCC tumor cells was activated, leading to metastasis.
- Subjects
CELL fusion; CELLULAR signal transduction; MACROPHAGES; SQUAMOUS cell carcinoma; METASTASIS
- Publication
Cancer Medicine, 2024, Vol 13, Issue 4, p1
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.6940