The authors comment on the article "Effect of Biotherapies on Fatigue in Rheumatoid Arthritis: A Systematic Review of the Literature and Meta-Analysis," by Karine Chauffier and colleagues, published within the issue. They argue that fatigue is an important symptom in rheumatoid arthritis and should be a high priority in treating arthritic patients. They also note the efficacy of graded exercise and behavioral therapy in fatigue pain reduction.