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- Title
Applying the Lessons of the DPP to Clinical Practice.
- Authors
Inzucchi, Silvio E.; Sherwin, Robert S.
- Abstract
The aim of the study is to determine whether improvement in risk factors for type 2 diabetes with lifestyle change or metformin, Glucophage can prevent or delay diabetes. It was found that the incidence of diabetes was reduced by 58% in the lifestyle group and by 31% in the metformin group. The Diabetes Prevention Program assessed the long-held notion that diet and exercise could prevent or delay type 2 diabetes. Lifestyle intervention and metformin therapy both reduced the incidence of diabetes in patients at high risk, with the former being more effective than the latter. It is necessary to ensure proper implementation of the diet and exercise program. Patients who are unwilling or unable to undertake lifestyle change, early off-label therapy with an antihyperglycemic agent such as metformin can slow their progression to diabetes.
- Subjects
DIABETES; DISEASE risk factors; LIFESTYLES; DIET; DRUGS
- Publication
Clinical Diabetes, 2003, Vol 21, Issue 2, p91
- ISSN
0891-8929
- Publication type
Article
- DOI
10.2337/diaclin.21.2.91