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- Title
Inhibition of autophagy antagonizes breast cancer brain metastogenesis and augments the anticancer activity of lapatinib.
- Authors
Nawrocki, Steffan T.; Espitia, Claudia M.; Espinoza, Maria Janina Carrera; Jones, Trace M.; Gamble, Madison E.; Sureshkumar, Sruthi; Chang, Mengyang; Wang, Wei; Carew, Jennifer S.
- Abstract
This article explores the potential of inhibiting autophagy, a cellular process that breaks down and recycles damaged components, to improve the effectiveness of the cancer drug lapatinib in treating breast cancer brain metastases. The study found that inhibiting autophagy through genetic manipulation or using the drug hydroxychloroquine enhanced the anticancer activity of lapatinib and reduced the number of brain metastases in animal models. The combination treatment also extended animal survival compared to using lapatinib alone. The authors suggest that targeting autophagy could be a promising therapeutic approach for breast cancer brain metastases and call for further research in this area.
- Subjects
LAPATINIB; BRAIN cancer; ANTINEOPLASTIC agents; METASTATIC breast cancer; BREAST cancer; MICROMETASTASIS
- Publication
Clinical & Translational Medicine, 2024, Vol 14, Issue 4, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1662