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- Title
Reinforced Degradable Biocomposite by Homogenously Distributed Functionalized Nanodiamond Particles.
- Authors
Sun, Yang; Finne‐Wistrand, Anna; Waag, Thilo; Xing, Zhe; Yassin, Mohamed; Yamamoto, Akihito; Mustafa, Kamal; Steinmüller‐Nethl, Doris; Krueger, Anke; Albertsson, Ann‐Christine
- Abstract
Severe phase separation was observed in blending nanodiamond particle (n-DP) in poly(L-lactide-co-ε-caprolactone) (poly(LLA- co-CL)) scaffold. In this study we optimized the scaffold by the addition of 1-50% (w/w) polylactide modified n-DP (n-DP-PLA) or benzoquinone-modified n-DP (n-DP-BQ). Composed by 10% n-DP-PLA, composite had 6 times higher E-modulus in tensile test, whereas the maximum reinforcement can be higher than 15 times. However, n-DP-BQ composites conserved the mechanical properties, and thermal properties of the polymer substrate. The attachment, spreading and growth of UE7T13 cells on modified n-DP composites were similar to poly(LLA- co-CL), and independent to n-DP concentrations. In summary, a proper modified n-DP is the key to reinforce poly(LLA- co-CL) for tissue engineering.
- Subjects
NANODIAMONDS; POLYLACTIC acid; NANOCRYSTALS; BIODEGRADABLE plastics; PARTICLES
- Publication
Macromolecular Materials & Engineering, 2015, Vol 300, Issue 4, p436
- ISSN
1438-7492
- Publication type
Article
- DOI
10.1002/mame.201400387